Creutzfeldt-Jakob disease


Creutzfeldt-Jakob disease
= CJD
a rapidly progressive rare neurological disease, a form of human spongiform encephalopathy in which dementia progresses to death after a period of 3–12 months. There is no effective treatment. The causative agent is an abnormal prion protein that accumulates in the brain and causes widespread destruction of tissue. CJD typically affects middle-aged to elderly people. Some 15% of cases are due to a form of the disease that is inherited as an autosomal dominant trait but most cases are sporadic, susceptibility being genetically determined. A few cases of CJD are acquired: the agent is known to have been transmitted by tissue and organ transplantation and by human growth hormone injections, but the disease may take years to manifest itself. Variant Creutzfeldt-Jakob disease (vCJD) is the human form of bovine spongiform encephalopathy (BSE), which is most likely acquired by the ingestion of infected beef products. Patients are younger than those affected with sporadic CJD and present with psychiatric symptoms (e.g. depression, anxiety), which are followed after months by myoclonic jerks (see myoclonus) and dementia. [G. Creutzfeldt (1885–1964) and A. M. Jakob (1884–1931), German psychiatrists]

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  • Creutzfeldt–Jakob disease — Classification and external resources Tonsil biopsy in variant CJD. Prion Protein immunostaining. ICD 10 A …   Wikipedia

  • Creutzfeldt-Jakob disease — ► NOUN ▪ a fatal degenerative disease affecting nerve cells in the brain. ● new variant Creutzfeldt Jakob disease Cf. ↑new variant Creutzfeldt Jakob disease ORIGIN named after the German neurologists H. G. Creutzfeldt and A. Jakob, who first… …   English terms dictionary

  • Creutzfeldt-Jakob disease — [kroits΄felt yä′kōb, kroits΄feld yä′kôp] n. an incurable degenerative disease of the nervous system thought to be caused by an unusual virus that incubates in the body for many years before symptoms appear …   English World dictionary

  • Creutzfeldt-Jakob disease — Infobox Disease Name = Creutzfeldt Jakob disease Caption = DiseasesDB = 3166 ICD10 = ICD10|A|81|0|a|80, ICD10|F|02|1|f|00 ICD9 = ICD9|046.1 ICDO = OMIM = 123400 MedlinePlus = eMedicineSubj = neuro eMedicineTopic = 725 MeshID = D007562 Creutzfeldt …   Wikipedia

  • Creutzfeldt-Jakob disease — /kroyts felt yah kawp/, Pathol. a rare, usually fatal brain disorder caused by an unidentified pathogen and characterized by progressive dementia, blindness, and involuntary movements. Also, Creutzfeldt Jacob disease. Also called Jakob… …   Universalium

  • Creutzfeldt-Jakob disease — noun rare (usually fatal) brain disease (usually in middle age) caused by an unidentified slow virus; characterized by progressive dementia and gradual loss of muscle control • Syn: ↑CJD, ↑Jakob Creutzfeldt disease • Hypernyms: ↑brain disorder,… …   Useful english dictionary

  • Creutzfeldt-Jakob disease — Creutz·feldt Ja·kob disease also Creutz·feld Ja·kob disease .krȯits .felt .yä (.)kōb n a rare progressive fatal spongiform encephalopathy now usu. considered to be caused by a prion and marked by the development of porous brain tissue, premature …   Medical dictionary

  • Creutzfeldt–Jakob disease — [ˌkrɔɪtsfɛlt jakɒb] noun a fatal degenerative disease affecting nerve cells in the brain, believed to be caused by a prion. Phrases new variant Creutzfeldt–Jakob disease a form of the disease characterized by an early age of onset and possibly… …   English new terms dictionary

  • Creutzfeldt-Jakob disease — also Creutzfeld Jakob disease noun Etymology: Hans G. Creutzfeldt died 1964 German psychiatrist and Alfons M. Jakob died 1931 German psychiatrist Date: 1963 a rare progressive fatal encephalopathy caused by a prion and marked by development of… …   New Collegiate Dictionary

  • Creutzfeldt-Jakob disease — Creutz·feldt Ja·kob dis·ease || ‚krɔɪtsfelt jækÉ’b CJD, rare degenerative brain disease named after Hans G. Creutsfeldt and Alfons Jakob (disease is characterized by memory loss, jerky movements, stiff posture and seizures caused by a… …   English contemporary dictionary


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